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mini scaffold library  (TargetMol)


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    TargetMol mini scaffold library
    Mini Scaffold Library, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mini scaffold library/product/TargetMol
    Average 93 stars, based on 6 article reviews
    mini scaffold library - by Bioz Stars, 2026-06
    93/100 stars

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    Antimicrobial effects of 0390 against Escherichia coli . (A) Workflow of the in vitro high-throughput screening assay of the <t>MINI</t> Scaffold library, containing 5,033 <t>MINI</t> <t>molecules.</t> The OD value was determined by a microplate spectrophotometer. The structural formula and characteristics of a hit (hit compound), 0390 (6056–0390) were shown. H_acceptor: hydrogen bond acceptor count. H_donor: hydrogen bond donor count. B_rotN: rotatable bond count. LogP: oil- water partition coefficient. (B) Growth of E. coli ATCC 25922 after exposure to different concentrations of 0390 for 18 h. The experiment was repeated three times.
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    Antimicrobial effects of 0390 against Escherichia coli . (A) Workflow of the in vitro high-throughput screening assay of the MINI Scaffold library, containing 5,033 MINI molecules. The OD value was determined by a microplate spectrophotometer. The structural formula and characteristics of a hit (hit compound), 0390 (6056–0390) were shown. H_acceptor: hydrogen bond acceptor count. H_donor: hydrogen bond donor count. B_rotN: rotatable bond count. LogP: oil- water partition coefficient. (B) Growth of E. coli ATCC 25922 after exposure to different concentrations of 0390 for 18 h. The experiment was repeated three times.

    Journal: Frontiers in Microbiology

    Article Title: Identification of a small molecule 0390 as a potent antimicrobial agent to combat antibiotic-resistant Escherichia coli

    doi: 10.3389/fmicb.2022.1078318

    Figure Lengend Snippet: Antimicrobial effects of 0390 against Escherichia coli . (A) Workflow of the in vitro high-throughput screening assay of the MINI Scaffold library, containing 5,033 MINI molecules. The OD value was determined by a microplate spectrophotometer. The structural formula and characteristics of a hit (hit compound), 0390 (6056–0390) were shown. H_acceptor: hydrogen bond acceptor count. H_donor: hydrogen bond donor count. B_rotN: rotatable bond count. LogP: oil- water partition coefficient. (B) Growth of E. coli ATCC 25922 after exposure to different concentrations of 0390 for 18 h. The experiment was repeated three times.

    Article Snippet: Besides, all molecules in the MINI Scaffold Library were screened and filtered through their pharmaceutical and chemical properties, and adverse structures, such as toxicity and PAINS, were eliminated by TopScience, Shanghai, China.

    Techniques: In Vitro, High Throughput Screening Assay, Screening Assay, Spectrophotometry